The Weirdest People in the World?

Behavioral scientists routinely publish broad claims about human psychology and behavior in the world’s top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich and Democratic (WEIRD) societies. Researchers—often implicitly—assume that either there is little variation across human populations, or that these “standard subjects” are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species—frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, selfconcepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior—hence, there are no obvious a priori grounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions of human nature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges.external validity, population variability, experiments, cross-cultural research, culture, human universals, generalizability, evolutionary psychology, cultural psychology, behavioral economics

Local effective dynamics of quantum systems: A generalized approach to work and heat

By computing the local energy expectation values with respect to some local measurement basis we show that for any quantum system there are two fundamentally different contributions: changes in energy that do not alter the local von Neumann entropy and changes that do. We identify the former as work and the latter as heat. Since our derivation makes no assumptions on the system Hamiltonian or its state, the result is valid even for states arbitrarily far from equilibrium. Examples are discussed ranging from the classical limit to purely quantum mechanical scenarios, i.e. where the Hamiltonian and the density operator do not commute.Comment: 5 pages, 1 figure, published versio

Bond formation and slow heterogeneous dynamics in adhesive spheres with long--ranged repulsion: Quantitative test of Mode Coupling Theory

A colloidal system of spheres interacting with both a deep and narrow attractive potential and a shallow long-ranged barrier exhibits a prepeak in the static structure factor. This peak can be related to an additional mesoscopic length scale of clusters and/or voids in the system. Simulation studies of this system have revealed that it vitrifies upon increasing the attraction into a gel-like solid at intermediate densities. The dynamics at the mesoscopic length scale corresponding to the prepeak represents the slowest mode in the system. Using mode coupling theory with all input directly taken from simulations, we reveal the mechanism for glassy arrest in the system at 40% packing fraction. The effects of the low-q peak and of polydispersity are considered in detail. We demonstrate that the local formation of physical bonds is the process whose slowing down causes arrest. It remains largely unaffected by the large-scale heterogeneities, and sets the clock for the slow cluster mode. Results from mode-coupling theory without adjustable parameters agree semi-quantitatively with the local density correlators but overestimate the lifetime of the mesoscopic structure (voids).Comment: 10 pages, 8 figure

Leveraging Strategic Institutional Partnerships: Creating a Phased Learning Commons at the University of Idaho Library

Following an energizing reorganization of the first floor, the University of Idaho Library sought additional strategies to support student learning and success. Building on previous successful collaborations with the Dean of Students Office, the Library and Tutoring Services created a model to offer peer-tutoring services in the library. Several philosophical and practical guidelines were considered, and implementation of the service, while challenging, was ultimately successful. Strategies for proposing, building, and maintaining similar partnerships with student services units are discussed, with best practices offered for other institutions seeking similar collaboration

Critical behavior in an evolutionary Ultimatum Game

Experimental studies have shown the ubiquity of altruistic behavior in human societies. The social structure is a fundamental ingredient to understand the degree of altruism displayed by the members of a society, in contrast to individual-based features, like for example age or gender, which have been shown not to be relevant to determine the level of altruistic behavior. We explore an evolutionary model aiming to delve how altruistic behavior is affected by social structure. We investigate the dynamics of interacting individuals playing the Ultimatum Game with their neighbors given by a social network of interaction. We show that a population self-organizes in a critical state where the degree of altruism depends on the topology characterizing the social structure. In general, individuals offering large shares but in turn accepting large shares, are removed from the population. In heterogeneous social networks, individuals offering intermediate shares are strongly selected in contrast to random homogeneous networks where a broad range of offers, below a critical one, is similarly present in the population.Comment: 13 pages, 7 figure

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been extensively analyzed as TRAIL sensitizers, particularly in TRAIL-resistant renal cell carcinoma cells. Evaluation of rocaglamide and analogs identified 29 compounds that are able to sensitize TRAIL-resistant ACHN cells to TRAIL-induced, caspase-dependent apoptosis with sub-µM potency which correlated with their potency as protein synthesis inhibitors and with loss of cFLIP protein in the same cells. Rocaglamide alone induced cell cycle arrest, but not apoptosis. Rocaglates averaged 4–5-fold higher potency as TRAIL sensitizers than as protein synthesis inhibitors suggesting a potential window for maximizing TRAIL sensitization while minimizing effects of general protein synthesis inhibition. A wide range of other rocaglate effects (e.g. on JNK or RAF-MEK-ERK signaling, death receptor levels, ROS, ER stress, eIF4E phosphorylation) were assessed, but did not contribute to TRAIL sensitization. Other than a rapid loss of MCL-1, rocaglates had minimal effects on mitochondrial apoptotic pathway proteins. The identification of structurally diverse/mechanistically similar TRAIL sensitizing rocaglates provides insights into both rocaglate structure and function and potential further development for use in RCC-directed combination therapy.This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research. Research performed at Boston University was supported in part by NIH R35 GM118173. Work at the BU-CMD is supported by R24 GM111625. (HHSN261200800001E - National Cancer Institute, National Institutes of Health; Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research; R35 GM118173 - NIH; R24 GM111625)Published versio

Knot Fertility and Lineage

In this paper, we introduce a new type of relation between knots called the descendant relation. One knot $H$ is a descendant of another knot $K$ if $H$ can be obtained from a minimal crossing diagram of $K$ by some number of crossing changes. We explore properties of the descendant relation and study how certain knots are related, paying particular attention to those knots, called fertile knots, that have a large number of descendants. Furthermore, we provide computational data related to various notions of knot fertility and propose several open questions for future exploration.Comment: 20 pages, 11 figures, 14 table

Einseitiger Arterienastverschluss und retinale "white dots"

Zusammenfassung: Hintergrund: Seit den 1990er Jahre ist eine Zunahme der Inzidenz von Syphilis zu beobachten. Der klassische Verlauf der Syphilis lässt sich in drei Stadien unterteilen. Eine okuläre Beteiligung ist besonders im Stadium III möglich. Die Erkrankung ist durch antibiotische Therapie effizient behandelbar. Methode: Wir berichten über einen 38-jährigen Patienten, der sich wegen eines 2Wochen zuvor plötzlich aufgetretenen nasalen Gesichtsfeldausfalls und Schleiersehens am linken Auge vorstellte. Vorausgegangen war eine intravitreale Triamcinolon-Injektion 6Wochen zuvor bei vorwiegend linksseitigem zystoidem Makulaödem, das als Manifestation einer hypertensiven Retinopathie bei Blutdruckwerten um 200/130 interpretiert worden war. Ergebnisse: Biomikroskopisch zeigen sich links ein Arterienastverschluss temporal superior sowie multiple kleine, scharf begrenzte, weißlich-gelbliche epi- und intraretinale Flecken. Es besteht leichte Papillenrandunschärfe. In der Lues-Serologie finden sich hoch positive Titer. Nach Therapie mit Pencillin G i.v. über 2Wochen zeigt sich deutliche Regredienz der chorioretinitische Herde, jedoch Persistenz der Visusminderung und des Gesichtsfeldausfalls. Schlussfolgerung: Aufgrund der Zunahme der Inzidenz der Syphilis wird es immer wichtiger, die Erkrankung als Differenzialdiagnose nicht nur bei unklaren Symptomkomplexen, sondern auch in vermeintlich eindeutigen Situationen in Betracht zu ziehe